A TBPB-Mediated C-3 Cycloalkylation and Formamidation of 4-Arylcoumarin

作者:Singh Sarangthem Joychandra; Mir Bilal Ahmad; Patel Bhisma K
来源:European Journal of Organic Chemistry, 2018, 2018(8): 1026-1033.
DOI:10.1002/ejoc.201701677

摘要

<jats:p>A <jats:italic>tert</jats:italic>‐butyl peroxybenzoate (TBPB) mediated cycloalkylation and formamidation efficiently took place at 120 °C in chlorobenzene or the corresponding formamide, respectively. The cycloalkylation required the addition of acetic acid, whereas the formamidation proceeded in its absence. This radical‐mediated process tolerated a broad scope of substrates and provided the products in moderate to good yields.</jats:p>

  • 出版日期2018-2-28