Uptake of Chlorin e(6) Photosensitizer by Polystyrene-Diphenyloxazole-Poly(N-Isopropylacrylamide) Hybrid Nanosystem Studied by Electronic Excitation Energy Transfer

作者：Losytskyy M Yu^*; Vretik L O; Kutsevol N V; Nikolaeva O A; Yashchuk V M

来源：Nanoscale Research Letters, 2018, 13(1): 166.

DOI：10.1186/s11671-018-2584-4

• Styrene nanoparticles
• Stimuli-responsive materials
• PNIPAM
• Diphenyloxazole
• Conformation transition
• Chlorin e(6)
• Electronic excitation energy transfer
• Radiodynamic therapy

Polystyrene (PS)-diphenyloxazole (PPO) nanoparticles with attached cross-linked poly-N-isopropylacrylamide (PNIPAM) chains were obtained resulting in PS-PPO-PNIPAM hybrid nanosystems (NS). Fluorescence spectra of chlorin e(6) added to PS-PPO-PNIPAM hybrid NS revealed electronic excitation energy transfer (EEET) from PS matrix and encapsulated PPO to chlorin e(6). EEET efficiency increased strongly during 1 h after chlorin e(6) addition, indicating that uptake of chlorin e(6) by PNIPAM part of hybrid NS still proceeds during this time. Heating of PS-PPO-PNIPAM-chlorin e(6) NS from 21 to 39 degrees C results in an enhancement of EEET efficiency; this is consistent with PNIPAM conformation transition that reduces the distance between PS-PPO donors and chlorin e(6) acceptors. Meanwhile, a relatively small part of chlorin e(6) present in the solution is bound by PNIPAM; thus, further studies in this direction are necessary.

• 出版日期2018-5-31