Vitamin D and Mammographic Findings

作者：Riedel J; Straub L; Wissing J; Artmann A; Schmidmayr M; Kiechle M; Seifert Klauss V R^*

来源：Geburtshilfe und Frauenheilkunde, 2016, 76(5): 570-578.

DOI：10.1055/s-0042-106208

• mammographic density
• vitamin D
• calcitriol
• breast cancer risk

Introduction: Pleiotropic immune-modulatory and anti-proliferative effects of vitamin D and hopes to stop cancerogenesis have led to an increased interest in possible reduction of breast cancer with higher vitamin D levels. Mammographic density is an established risk factor for breast cancer risk, and its association with serum vitamin D is complex, as recent studies have shown.
Patients and Methods: In this cross-sectional study, 1103 participants were recruited in the breast diagnostic unit of the Klinikum rechts der Isar, TU Munich. A standardised questionnaire and blood samples for 25-OH-vitamin Dwere taken on the day of mammography. Histologic results of biopsies in suspicious mammographies were documented.
Results: In the 1090 data-sets analysed, vitamin D-deficiency was common among women under 40. Highest vitamin D values were observed in participants aged 60-69 years, but average values for all age cohorts were below 20 ng/ml of vitamin D. 15.6% of all participants had very low vitamin D values (<10 ng/ml), 51.3% were vitamin Ddeficient (10-19 ng/ml) and only 5.7% were above 30 ng/ml, i.e. showed sufficient vitamin D. Patients with malignant results had vitamin D <10 ng/ml more often (16.9%; p = 0.61), and only 3.4% in this group had sufficient vitamin D supply (> 30 ng/ml). There were no significant differences in vitamin D-levels between density groups according to the American College of Radiology (ACR) criteria.
Conclusion: Vitamin D values were lower than in comparable US women. Up to now, there is no direct clinical evidence for a relationship between the risk for breast cancer and a specific vitamin D value.

• 出版日期2016-5