An efficient synthesis, spectral characterization, antimicrobial, and antioxidant activities of novel alpha-hydroxyphosphonates and alpha-hydroxyphosphinates

作者：Sampath C; Raju C Naga; Rao C Venkata^*

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191(1): 95-99.

DOI：10.1080/10426507.2015.1032412

• alpha -Hydroxyphosphonates
• alpha-hydroxyphosphinates
• antimicrobial activity
• antioxidant activity

A simple, novel, and an efficient synthesis of -hydroxy phosphonates (3a-d) and phosphinates (5a-f) has been accomplished from febuxostat aldehyde (1) with various dialkylphosphites (2) and dialkylphosphinates (4) in the presence of 1, 4-dimethylpiperazine as a strong base with good to excellent yields (78%-95%) is reported. The structures of the title compounds were established by elemental analysis and spectral data (IR, H-1, C-13 and P-31 NMR, and LC-MS). All the title compounds (3a-d) and (5a-f) were tested for their antimicrobial and antioxidant activities. Bioassay results reveal that a few of the title compounds exhibited promising antimicrobial and antioxidant activities.

• 出版日期2016-1-2