Aqueous microwave-assisted one-pot synthesis of N-substituted rhodanines

作者：Nitsche Christoph; Klein Christian D^*

来源：Tetrahedron Letters, 2012, 53(39): 5197-5201.

DOI：10.1016/j.tetlet.2012.07.002

• Rhodanine
• Microwave
• Multicomponent reaction
• Green chemistry
• Cyclization

Two aqueous, one-pot, microwave-assisted methods for the rapid synthesis of N-substituted rhodanines from amine substrates are described. Alkyl- and benzylamines could be converted into the corresponding rhodanines with an atom-efficient one-pot, three-step protocol based on carbon disulfide and chloroacetic acid in short reaction times and good to excellent yields. An alternative, microwave-assisted one-pot, one-step protocol using bis(carboxymethyl)trithiocarbonate in water was developed for the synthesis of N-arylrhodanines from anilines.

• 出版日期2012-9-26