A prospective study of neuropsychological functioning in testicular cancer patients

作者：Skaali T^*; Fossa S D; Andersson S; Cvancarova M; Langberg C W; Lehne G; Dahl A A

来源：Annals of Oncology, 2011, 22(5): 1062-1070.

DOI：10.1093/annonc/mdq553

• chemotherapy
• cognitive function
• neuropsychological functioning
• neurotoxicity
• prospective study
• testicular cancer patients

Background: Whether systemic chemotherapy has a negative effect on cognitive function in patients, concern oncologists. In testicular cancer patients (TCPs) treated with cisplatin-based chemotherapy, only few cross-sectional studies have addressed this concern. We prospectively studied neuropsychological functioning in TCPs.
Patients and methods: In a consecutive sampling, 122 TCPs were examined at baseline (after orchidectomy, before any additional treatment) and then at follow-up at a median of 12 months after end of treatment. The examinations included a neuropsychological test battery, interview on background variables and questionnaires on mental distress, fatigue and neurotoxic symptoms. Changes in neuropsychological functioning from baseline to follow-up were compared between three treatments groups: no chemotherapy (N = 31), one cycle of chemotherapy (N = 38) and two or more cycles of chemotherapy (N = 53). Variables associated with a decline in neuropsychological test performance from baseline to follow-up were explored.
Results: No statistically significant differences in proportions of TCPs with a decline in neuropsychological test performance were observed between the three treatment groups. Decline in neuropsychological test performance was not associated with demographic variables, distress, fatigue or with chemotherapy.
Conclusion: No negative effect of systemic chemotherapy on neuropsychological test performance in TCPs at 1-year follow-up was found in this study.

• 出版日期2011-5