A systematic review and meta-analysis of the association of transforming growth factor beta receptor I 6A/9A gene polymorphism with ovarian cancer risk

作者：Liu, Li-Ling; Wei, Ye-Ping; Xu, Hong^*; Huang, Yan; Luo, Feng-E; Huang, Zhu-Juan; Mai, Hong; Deng, Li; Yin, Yan

来源：Journal of Receptors and Signal Transduction, 2014, 34(4): 313-316.

DOI：10.3109/10799893.2014.885051

• 6A/9A
• gene polymorphism
• ovarian cancer
• meta-analysis
• transforming growth factor beta receptor

Ovarian cancer is the leading cause of cancer-related death in women. This meta-analysis was conducted to evaluate the association of transforming growth factor beta receptor I (T beta R-I) 6A/9A gene polymorphism with ovarian cancer risk. The association literatures were identified from PubMed and Cochrane Library on 1 October 2013, and eligible reports were recruited and synthesized. Four reports were recruited into this meta-analysis for the association of T beta R-I 6A/9A gene polymorphism with ovarian cancer risk. 6A allele and 6A/6A genotype of T beta R-I were associated with the ovarian cancer risk (6A: OR=1.24, 95% CI: 1.02-1.51, p=0.03; 6A/6A: OR=2.30, 95% CI: 1.01-5.22, p=0.05). However, T beta R-I 9A/9A genotype was not associated with the risk of ovarian cancer (OR=0.82, 95% CI: 0.66-1.02, p=0.08). In conclusion, T beta R-I 6A allele and 6A/6A genotype are associated with the ovarian cancer risk. However, more studies should be performed to confirm this relationship in the future.

• 出版日期2014-8
• 单位广西医科大学