Participation of muscarinic and nicotinic cholinoreceptors of hypothalamic preoptic area in control of thermoregulation and of wakefulness and sleep states in the pigeons Columba livia

作者：Komarova T G^*; Ekimova I V; Pastukhov Yu F

来源：Journal of Evolutionary Biochemistry and Physiology, 2007, 43(4): 398-403.

DOI：10.1134/S0022093007040047

• ventrolateral preoptic area
• muscarinic and nicotinic cholinoreceptors
• sleep
• wakefulness
• thermoregulation
• pigeons

By using electrophysiological methods, it has been established that muscarinic (M-) cholinergic mechanisms of the ventrolateral preoptic area (VLPA) of pigeon hypothalamus participate in maintenance of wakefulness, whereas nicotinic (N-) mechanisms-in maintenance of the nonrapid-eye movement sleep (slow sleep). Activation of the VLPA M-cholinergic receptors has been found to be accompanied by an elevation of the brain temperature, by development of peripheral vasoconstriction, and by an increase in the muscle contractive activity. Activation of N-cholinoreceptors leads to a decrease in the brain temperature and development of peripheral vasoconstriction. It is suggested that the VLPA M-and N-cholinergic receptors are involved in different mechanisms of regulation of wakefulness and sleep states and brain temperature in pigeons.

• 出版日期2007-8