Asymmetrical synthesis of fluorinated 2-(pyridin-2-yl) alkylamine from fluoromethyl sulfinyl imines and 2-alkylpyridines

作者：Yang, Jialin; Zhang, Jiali; Meng, Weidong; Huang, Yangen^*

来源：Tetrahedron Letters, 2015, 56(47): 6556-6559.

DOI：10.1016/j.tetlet.2015.10.005

• 2-Alkylpyridines
• Chiral auxiliary
• Trifluoromethyl
• Nucleophilic addition
• Asymmetric

A novel strategy was developed to synthesize fluorinated 2-(pyridin-2-yl) alkylamines via condensation of 2-alkylpyridines and chiral fluoromethyl N-tert-butyl sulfinyl imines with good diastereo-control and good chemical yields. The chiral N-tert-butyl sulfinyl auxiliary can be easily removed under mild acidic condition at room temperature. The application of this strategy was demonstrated in the synthesis of a fluorine-containing pesticide candidate.

• 出版日期2015-11-25
• 单位东华大学