Mathematical modeling of the coating process

作者：Toschkoff Gregor; Khinast Johannes G^*

来源：International Journal of Pharmaceutics, 2013, 457(2): 407-422.

DOI：10.1016/j.ijpharm.2013.08.022

• Film coating
• Tablet coating
• Discrete Element Method (DEM)
• Computational Fluid Dynamics (CFD)
• Modeling
• Pharmaceutical Engineering

Coating of tablets is a common unit operation in the pharmaceutical industry. In most cases, the final product must meet strict quality requirements; to meet them, a detailed understanding of the coating process is required. To this end, numerous experiment studies have been performed. However, to acquire a mechanistic understanding, experimental data must be interpreted in the light of mathematical models. In recent years, a combination of analytical modeling and computational simulations enabled deeper insights into the nature of the coating process. %26lt;br%26gt;This paper presents an overview of modeling and simulation approaches of the coating process, covering various relevant aspects from scale-up considerations to coating mass uniformity investigations and models for drop atomization. The most important analytical and computational concepts are presented and the findings are compared.

• 出版日期2013-12-5