Diastereoselective alkylation reactions employing a new camphor-based 2-phenylimino-2-oxazolidine chiral auxiliary

作者：Zhang Long Duo; Lu Cui Fen; Chen Zu Xing; Yang Gui Chun; Nie Jun Qi^*

来源：Chinese Chemical Letters, 2014, 25(11): 1466-1468.

DOI：10.1016/j.cclet.2014.05.044

• Chiral auxiliaries
• Alkylation
• Asymmetric catalysis
• Camphor-based

A new camphor-based 2-phenylimino-2-oxazolidine chiral auxiliary was prepared and it was shown to be a particularly effective chiral auxiliary for asymmetric alkylations affording high yields and diastereoselectivities. The alkylation products were readily cleaved by simple alkaline hydrolysis to give alpha-alkylated carboxylic acids in good yield and in almost enatiomerically pure form.

• 出版日期2014-11
• 单位湖北大学