A polymeric nanoparticle formulation of curcumin (NanoCurc (TM)) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation

作者：Bisht Savita; Khan Mehtab A; Bekhit Mena; Bai Haibo; Cornish Toby; Mizuma Masamichi; Rudek Michelle A; Zhao Ming; Maitra Amarnath; Ray Balmiki; Lahiri Debomoy; Maitra Anirban; Anders Robert A^*

来源：Laboratory Investigation, 2011, 91(9): 1383-1395.

DOI：10.1038/labinvest.2011.86

• carbon tetrachloride
• cirrhosis
• curcumin
• cytokines
• liver fibrosis
• myofibroblasts
• NanoCurct (TM)
• polymeric nanoparticle

Plant-derived polyphenols such as curcumin hold promise as a therapeutic agent in the treatment of chronic liver diseases. However, its development is plagued by poor aqueous solubility resulting in poor bioavailability. To circumvent the suboptimal bioavailability of free curcumin, we have developed a polymeric nanoparticle formulation of curcumin (NanoCurct (TM)) that overcomes this major pitfall of the free compound. In this study, we show that NanoCurct (TM) results in sustained intrahepatic curcumin levels that can be found in both hepatocytes and non-parenchymal cells. NanoCurct (TM) markedly inhibits carbon tetrachloride-induced liver injury, production of pro-inflammatory cytokines and fibrosis. It also enhances antioxidant levels in the liver and inhibits pro-fibrogenic transcripts associated with activated myofibroblasts. Finally, we show that NanoCurct (TM) directly induces stellate cell apoptosis in vitro. Our results suggest that NanoCurct (TM) might be an effective therapy for patients with chronic liver disease. Laboratory Investigation (2011) 91, 1383-1395; doi: 10.1038/labinvest.2011.86; published online 20 June 2011

• 出版日期2011-9