Antinociceptive activity of the extract of Erythroxylum caatingae

作者：Holanda Leite Maia Ana Karina; Bezerra De Queiroz Ronaldo; Vilar Da Fonseca Diogo; Silveira Pinho Andre; Golzio Dos Santos Scrates; Lima De Alencar Jacicarlos; Fechine Tavares Josean; Nobrega De Almeida Reinaldo^*; Clebia Soares Lima De Morais Liana

来源：Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2014, 13(2): 152-162.

• Erythroxylum caatingae
• medicinal plant
• antinociceptive activity
• pain

The genus Erythoxylum plants are popularly used as anti-inflammatory, anti-bacterial, and diuretic agentes, and for treating of respiratory problems. This study investigated the antinociceptive activity of methanolic extract of Erythroxylum caatingae (EcME) in chemical (formalin test and acetic acid test) and thermal models (hot plate test) of nociception. Intraperitoneal pre-treatment with EcME reduced the number of abdominal contortions and the licking time in the second phase of the formalin test. EcME did not show a significant effect in the hot plate test, rota-rod test, and the elevated plus maze test. These findings indicate that the antinociceptive activity of EcME is not because of a depressor effect on the central nervous system, and EcME is not a muscle relaxant. Nevertheless, Erythroxylum caatingae demonstrated peripheral antinociceptive activity, which confirms its popular use and contributes to the scientific knowledge of the species.

• 出版日期2014-3