Morphologic abnormalities in 2-year-old children born after in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening: follow-up of a randomized controlled trial

作者：Beukers Fenny; van der Heide Maaike; Middelburg Karin J; Cobben Jan Maarten; Mastenbroek Sebastiaan; Breur Rinske; van der Lee Johanna H; Hadders Algra Mijna; Bos Arend F; Kok Joke H^*

来源：Fertility and Sterility, 2013, 99(2): 408-+.

DOI：10.1016/j.fertnstert.2012.10.024

• PGS
• IVF
• morphologic abnormality
• follow-up
• children

Objective: To evaluate the effect of preimplantation genetic screening (PGS) on morphologic outcome in children. %26lt;br%26gt;Design: Follow-up of a randomized controlled trial (RCT). %26lt;br%26gt;Setting: University hospital. %26lt;br%26gt;Patient(s): Two-year-old children born to mothers who participated in an RCT on the efficacy of PGS: 50 children born after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) with PGS (intervention group; PGS+) and 72 children born after IVF/ICSI only (control group; PGS-). Sixty-six age-matched children conceived without any form of assisted reproduction were recruited separately in a local public health service center (reference group). %26lt;br%26gt;Intervention(s): PGS. %26lt;br%26gt;Main Outcome Measure(s): Body surface examination and anthropometry. The evaluation of morphologic abnormalities allowed assessment of children%26apos;s phenotype in detail. Morphologic abnormalities were classified as major abnormalities (abnormal development in organogenesis, deformations, disruptions, or dysplasia) and minor anomalies (deviations in phenogenesis). %26lt;br%26gt;Result(s): The percentage of children with %26gt;= 1 major abnormality was 28% in the PGS+ and 35% in the PGS - group [difference - 7%, 95% CI - 23% to 10%]. The percentage of children with %26gt;= 1 minor anomaly was 64% in the PGS+ and 67% in the PGS - group [difference - 3%, 95% CI - 15% to 20%]. In the reference group 30% of the children had %26gt;= 1 major abnormality [95% CI 20% to 43%] and 74% had %26gt;= 1 minor anomaly [95% CI 62% to 84%]. %26lt;br%26gt;Conclusion(s): No statistically significant differences were found in minor anomalies between children conceived after IVF/ICSI with or without PGS. There is %26lt;2.5% chance of %26gt;= 10% more major abnormalities in children born after PGS. (Fertil Steril (R) 2013;99:408-13.

• 出版日期2013-2