Usefulness of low-dose CT in the detection of pulmonary metastasis of gestational trophoblastic tumours

作者：Xu X J; Lou F L; Zhang M M^*; Pan Z M; Zhang L

来源：Clinical Radiology, 2007, 62(10): 998-1003.

DOI：10.1016/j.crad.2007.03.009

AIM: To determine whether a low-dose spiral. chest computed tomography (CT) examination could replace standard-dose chest CT in detecting pulmonary metastases in patients with gestational trophoblastic tumour (GTT).
MATERIALS AND METHODS: In a prospective investigation, 67 chest CT examinations of 39 GTT patients were undertaken. All the patients underwent CT examinations using standard-dose (150 mAs, pitch 1, standard reconstruction algorithm) and low-dose, (40 mAs, pitch 2, bone reconstruction algorithm) protocols. Two radiologists interpreted images independently. A metastasis was defined as a nodule within lung parenchyma that could not be attributed to a pulmonary vessel. The number of metastases detected with each protocol was recorded. The size of each lesion was measured and categorized as < 5, 5-9.9, and >= 10 mm. Wilcoxon's signed rank test was used to assess the difference between the numbers of lesion detected by the two protocols.
RESULTS: The CT dose index (CTDI) for the standard-dose and low-dose CT protocols was 10.4 mGy and 1.4 mGy, respectively. One thousand, six hundred, and eighty-two metastases were detected by standard-dose CT, and 1460 lesions by the low-dose protocol. The numbers detected by low-dose CT were significantly less than those detected by standard-dose CT (Z = -3.776, p < 0.001), especially for nodules smaller than 5 mm (Z = -4.167, p < 0.001). However, the disease staging and risk score of the patients were not affected by use of the tow-dose protocol.
CONCLUSION: Low-dose chest CT can be used as a staging and follow-up procedure for patients with GTT.

• 出版日期2007-10
• 单位浙江大学