A flexible carbanionic approach to protected trans-(2R,3S)-2-substituted 3-aminopyrrolidines: application to the asymmetric synthesis of (+)-absouline

作者：Tang T; Ruan YP; Ye JL; Huang PQ^*

来源：Synlett, 2005, (2): 231-234.

DOI：10.1055/s-2004-837194

• asymmetric synthesis
• additions
• pyrrolidine
• carbanions
• reductive lithiation

Based on the use of phenyl thioether (3S)-7 as a synthetic equivalent to the N- and alpha-dianions (3S)-2a, a new carbanionic approach to trans-(2R,3S)-2-substituted 3-aminopyrrolidines (10) is described. Application of the method to the asymmetric synthesis of 1-aminopyrrolizidine alkaloid (+)-absouline is also reported.

• 出版日期2005-2-1
• 单位厦门大学; 南开大学