Association of Copper Transporter Expression with Platinum Resistance in Epithelial Ovarian Cancer

作者：Yoshida Hiroyuki^*; Teramae Masatomo; Yamauchi Makoto; Fukuda Takeshi; Yasui Tomoyo; Sumi Toshiyuki; Honda Ken Ichi; Ishiko Osamu

来源：Anticancer Research, 2013, 33(4): 1409-1414.

• Ovarian cancer
• chemotherapy resistance
• copper transporter

Background: Copper transporters (CTR) also regulate the cellular transport of platinum drugs, but their role in platinum resistance of ovarian cancer has not been elucidated. Materials and Methods: CTR expression in ovarian cancer tissues resected from patients treated by platinum-based chemotherapy was evaluated immunohistochemically. CTR2 expression in ovarian cancer cells was inhibited by bathocuproine disulfonate, and the changes in cisplatin sensitivity were examined. Results: CTR2 expression was increased in chemoresistant patients, but not significantly. However, the CTR2/CTR1 ratio was significantly increased in chemoresistant patients. Cases with positive CTR2 expression or positive CTR2/CTR1 ratio had poor prognoses. When the CTR2 expression in ovarian cancer cells was suppressed, sensitivity to cisplatin was significantly increased. Conclusion: These data suggest that CTR2 contributes to platinum resistance in ovarian cancer. The CTR2/CTR1 ratio is a useful marker for platinum sensitivity and a potential prognostic factor in patients with ovarian cancer.

• 出版日期2013-4