Multicentre patch testing with a resol resin based on phenol and formaldehyde

作者：Isaksson Marlene^*; Inerot Annica; Liden Carola; Matura Mihaly; Stenberg Berndt; Moller Halvor; Bruze Magnus

来源：Contact Dermatitis, 2011, 65(1): 34-37.

DOI：10.1111/j.1600-0536.2011.01921.x

• baseline series
• formaldehyde
• phenol-formaldehyde resins
• p-tertiary-butylphenol-formaldehyde resin
• simultaneous contact allergy

Background. Contact allergy to phenol-formaldehyde resins (PFRs) based on phenol and formaldehyde is not detected by a p-tertiary-butylphenol-formaldehyde resin (PTBP-FR) included in most baseline patch test series.
Objectives. To investigate the rate of contact allergy to PFR-2 (a mixture of monomers and dimers from a resol resin based on phenol and formaldehyde) in a Swedish population, and to investigate associated simultaneous allergic reactions.
Methods. Five centres representing the Swedish Contact Dermatitis Research Group included PFR-2 in their patch test baseline series for a period of 1.5 years.
Results. Of 2504 patients tested, 27 (1.1%) reacted to PFR-2. Of those 27 individuals, 2 had a positive reaction to formaldehyde and 2 to PTBP-FR. Simultaneous allergic reactions were noted to colophonium in 6, to Myroxylon pereirae in 14, and to fragrance mix I in 15.
Conclusions. The contact allergy frequency in the tested population (1.1%) merits its inclusion in the Swedish baseline series and possibly also in other baseline series. Simultaneous allergic reactions were noted to colophonium, M. pereirae, and fragrance mix I.

• 出版日期2011
• 单位东北大学