A novel role for the marrow microenvironment in initiating and sustaining hematopoietic disease

作者：Ramakrishnan Aravind; Deeg H Joachim^*

来源：Expert Opinion on Biological Therapy, 2009, 9(1): 21-28.

DOI：10.1517/14712590802603093

• hematological malignancy
• hematopoesis
• marrow microenvironment
• stromal cells

Background: The marrow microenvironment is composed of a complex network of cells and extra cellular matrix that cooperate to regulate normal hematopoiesis. There is growing evidence that microenvironmental defects can contribute to the pathogenesis of hematological malignancies. Objective/methods: We review the role of the microenvironment in inducing and sustaining hematological malignancies. Results/conclusions: Two basic mechanisms could explain the role of microenvironmental defects in the evolution of hematopoietic neoplasms. There is significant data to support the first mechanism, in which the malignant hematopoietic clone induces reversible functional changes in the microenvironment that result in improved growth conditions for the malignant cells. More recent studies from mouse models have indicated that a second mechanism involving primary microenvironmental defects can also result in malignancy.

• 出版日期2009-1