Guarana (Paullinia cupana Mart.) Prevents beta-Amyloid Aggregation, Generation of Advanced Glycation-end Products (AGEs), and Acrolein-Induced Cytotoxicity onHuman Neuronal-Like Cells

作者：Bittencourt Leonardo da Silva^*; Zeidan Chulia Fares; Jorge Yatsu Francini Kiyono; Schnorr Carlos Eduardo; Moresco Karla Suzana; Kolling Eduardo Antonio; Gelain Daniel Pens; Bassani Valquiria Linck; Fonseca Moreira Jose Claudio

来源：Phytotherapy Research, 2014, 28(11): 1615-1624.

DOI：10.1002/ptr.5173

• Alzheimer's disease
• natural products
• neurodegenerative diseases
• neuroprotection
• polyphenols
• caffeine

Advanced glycation end-products (AGEs) are considered potent molecules capable of promoting neuronal cell death and participating in the development of neurodegenerative disorders such as Alzheimer's disease (AD). Previous studies have shown that AGEs exacerbate -amyloid (A) aggregation and AGE-related cross-links are also detected in senile plaques. Acrolein (ACR) is an , -unsaturated aldehyde found in the environment and thermally processed foods, which can additionally be generated through endogenous metabolism. The role of ACR in AD is widely accepted in the literature. Guarana (Paullinia cupana Mart.) is popularly consumed by the population in Brazil, mainly for its stimulant activity. In the present study, we showed that guarana (10, 100, and 1000 mu g/mL) is able to prevent protein glycation, -amyloid aggregation, in vitro methylglyoxal, glyoxal, and ACR (20M)-induced toxicity on neuronal-like cells (SH-SY5Y). Since these are considered typical AD pathological hallmarks, we propose that guarana may deserve further research as a potential therapeutic agent in such a neurodegenerative disease.

• 出版日期2014-11