Anti-hepatitis B virus constituents from the stem bark of Streblus asper

作者：Li, Jun; Huang, Yan; Guan, Xin-Lan; Li, Jian; Deng, Sheng-Ping; Wu, Qiang; Zhang, Yan-Jun; Su, Xiao-Jian; Yang, Rui-Yun

来源：Phytochemistry, 2012, 82: 100-109.

DOI：10.1016/j.phytochem.2012.06.023

• Streblus asper
• Moraceae
• (7 ' S.8 ' S)-trans-streblusol A
• Streblusquinone
• Streblusol E
• Anti-HBV

Seven compounds, (7'S,8'S)-trans-streblusol A, (7'R,8'S)-erythro-streblusol B, (7'S,8'S)-threo-streblusol B, 8'R-streblusol C, streblusquinone, (8R,8'R)-streblusol D, and streblusol E, along with 15 known compounds (8-22) were isolated from the n-butanol-soluble part of the MeOH extract of stem bark of Streblus aspen Their structures were elucidated through application of extensive spectroscopic methods, including ESI-MS and 20 NMR spectroscopy (HMQC and FIMBC). The stereochemistry at the chiral centers was determined using CD spectra, as well as analyses of coupling constants and optical rotation data. The isolated lignans and allylbenzene derivatives were evaluated for their anti-HBV activities in vitro using the HBV transfected Hep G2.2.15 cell line. The most active compounds, magnolol and 9-beta-xylopyranosyl-isolariciresinol, exhibited significant anti-HBV activities with IC50 values of 2.03 and 6.58 mu M for secretion of HBsAg, with no cytotoxicity, and of 3.76 and 24.86 mu M for secretion of HBeAg, with no cytotoxicity.

• 出版日期2012-10
• 单位广西师范大学