Association of GSTM1 and GSTT1 with ageing in auto repair shop workers

作者：Eshkoor S A; Marashi S J; Ismail P^*; Rahman S A; Mirinargesi M; Adon M Y; Devan R V

来源：Genetics and Molecular Research, 2012, 11(2): 1486-1496.

DOI：10.4238/2012.May.21.5

• GST genes
• Ageing
• Occupational exposure
• Comet assay
• Micronucleus test
• Multiplex PCR

We evaluated the possible influence of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) genes on genetic damage due to occupational exposure, which contributes to accelerate ageing. This study was conducted on 120 car auto repair workshop workers exposed to occupational hazards and 120 controls without this kind of exposure. The null and non-null genotypes of GSTM1 and GSTT1 genes were determined by multiplex PCR. Micronucleus frequency, Comet tail length and relative telomere length differences between the null and non-null genotypes of the GSTM1 gene were significantly greater in the exposed group. Lack of GSTT1 did not affect the damage biomarkers significantly (P %26gt; 0.05), while lack of GSTM1 was associated with greater susceptibility to genomic damage due to occupational exposure. It was concluded that early ageing is under the influence of these genes and the environmental and socio-demographic factors. Duration of working time was significantly associated with micronucleus frequency, Comet tail length and relative telomere length.

• 出版日期2012
• 单位河北医科大学