Aging and glycoxidant stress

作者：Peppa Melpomeni^*; Uribarri Jaime; Vlassara Helen

来源：Hormones-International Journal of Endocrinology and Metabolism, 2008, 7(2): 123-132.

• Advanced Glycation End products
• AGES
• AGE receptors
• Aging
• Glycoxidant stress
• Inflammation
• Oxidative stress

Aging and related diseases are accompanied by increased Oxidative Stress (OS) and accumulation of Advanced Glycation End products (AGES). One important component of AGES accumulation with aging appears to be the sustained exposure to dietary AGE (dAGEs), which contributes to overloading of anti-AGE receptors and depletion of anti-oxidant reserves. In this review, we present experimental animal and human data which support this postulation. Lowering the content of AGES in the normal diet significantly prevents AGES accumulation and the increased OS caused by aging and also extends lifespan in mice. In humans, short-term trials indicate that a Low AGES diet reduces oxidant burden and inflammatory markers. Long-term studies are in progress and will help establish definitive causality between age-related disease states and modern dietary practices in Western societies.

• 出版日期2008-6