Asymmetric Synthesis of Hydroisoquinoline Derivatives, a Key intermediate for Manzamine Synthesis, by Diels-Alder Reaction Using 4-Amino-2-siloxybutadiene

作者：Mihara Yasuhiro; Matsumura Tomoaki; Terauchi Yuki; Akiba Masakatsu; Arai Shigeru; Nishida Atsushi^*

来源：Bulletin of the Chemical Society of Japan, 2009, 82(12): 1520-1527.

DOI：10.1246/bcsj.82.1520

A novel method for the synthesis of chiral hydroisoquinolines by asymmetric Diels-Alder reaction of nitrogen-containing dienophiles and suitably protected aminosiloxybutadienes has been developed. The product could be a key intermediate for synthesis of manzamine alkaloids.

• 出版日期2009-12-15