Association of serum 25-hydroxy vitamin D and osteocalcin levels with non-alcoholic fatty liver disease

作者：Hu, Xiaolei^*; Hua, Yaowu; Shi, Zhaoming; Song, Yining; Zhang, Shirong; Zhou, Jing; Sun, Weihua

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(11): 22750-22757.

• 25-hydroxy vitamin D
• osteocalcin
• non-alcoholic fatty liver disease

Considering the strong association of non-alcoholic fatty liver disease (NAFLD) with obesity and the metabolic syndrome, recent researches have witnessed a significant scientific interest into the potential role of vitamin D or osteocalcin in NAFLD, but the relationship between them remains controversial. The present study was designed to investigate the association of serum 25-hydroxy vitamin D (25-OH-VitD) and osteocalcin levels with NAFLD. A total of 398 participants who were referred to our endocrinology outpatient clinics and health examination center were recruited from November 2014 to February 2015. After screening, 368 patients were included in the study finally. Serum 25-OH-VitD was determined by radioimmunoassay and serum osteocalcin was determined by immunoradiometric assay. NAFLD was diagnosed by hepatic ultrasonographic examination. The association of serum 25-OH-VitD and osteocalcin with NAFLD was evaluated. Among the participants, 190 did not have NAFLD (non-NAFLD group), 178 had NAFLD (NAFLD group). The levels of serum 25-OH-VitD and osteocalcin were lower in NAFLD group than those in non-NAFLD group (P < 0.001). Serum 25-OH-VitD and osteocalcin levels were associated with the NAFLD (P < 0.001). Serum 25-OH-VitD and osteocalcin levels were protective factors for the development of NAFLD (P < 0.001). Our findings suggest that lower serum 25-OH-VitD and osteocalcin levels are associated with the presence of NAFLD.

• 出版日期2016
• 单位蚌埠医学院