Association between cytokine gene polymorphisms and cervical cancer in a Chinese population

作者：Wang Qian; Zhang Chenhua; Walayat Shah; Chen Hong Wei^*; Wang Yili

来源：European Journal of Obstetrics & Gynecology and Reproductive Biology, 2011, 158(2): 330-333.

DOI：10.1016/j.ejogrb.2011.05.019

• Cervical cancer
• Polymorphisms
• Risk factor

Objectives: It has been hypothesized that inherited cytokine gene polymorphisms could influence susceptibility to cervical cancer. This study evaluated the association between tumour necrosis factor-alpha (TNF-alpha)-308, transforming growth factor-beta 1 (TGF-beta 1), interferon-gamma (IFN-gamma)+874 and interleukin-10 (IL-10)-1082 gene polymorphisms and cervical cancer risk.
Study design: The study population included 186 histopathologically confirmed cases of cervical cancer and 200 healthy controls. TNF-alpha, TGF-beta, IL-10 and IFN-gamma gene polymorphisms were genotyped by polymerase chain reaction with sequence-specific primers.
Results: The IFN-gamma+874A/A genotype was associated with high risk for the development of cervical cancer [odds ratio (OR) 2.22, p = 0.012], and the A allele was associated with a 1.47-fold increased risk of cervical cancer (p = 0.009). In contrast, no significant difference was found in the frequencies of TNF-alpha-308G/A, TGF-beta 1 codons 10 and 25 C/C-G/G and IL-10-1082G/A gene polymorphisms between patients with cervical cancer and healthy controls.
Conclusions: Homozygous IFN-gamma+874A/T polymorphisms may be associated with increased risk for the development of cervical cancer.

• 出版日期2011-10
• 单位西安交通大学