Phytochemical and biological studies of Carduus pycnocephalus L.

作者：Al Shammari Latifa A; Hassan Wafaa H B^*; Al Youssef Hanan M

来源：Journal of Saudi Chemical Society, 2015, 19(4): 410-416.

DOI：10.1016/j.jscs.2012.05.002

• C. pycnocephalus L.
• Flavonoids
• Palustroside
• Antispasmodic
• Anti-inflammatory

Seven flavonoidal compounds, apigenin (1), kaempferol-3-O-beta-D-glucoside (2), kaempferol-3-O-alpha-L-rhamnoside (3), kaempferol-7-methoxy-3-O-alpha-L-rhamnoside (4), diosmetin-7-O-beta-D-xylosyl-(1'''-->6 '')-beta-D-glucopyranoside (5), diosmetin-7-O-alpha-L-arabinosyl (1'''-->6 '')-beta-D-glucopyranoside (6), kaempferol-3-O-alpha-L-rhamnosyl-(1'''-->2 '')-alpha-L-rhamnoside (7), in addition to lupeol (8), beta-sitosterol (9) and beta-sitosterol-3-O-beta-D-glucoside (10) were isolated from the aerial parts of Carduus pycnocephalus L. The structures of the isolated compounds were established by UV, IR, FAB-MS, ESI-MS, EI-MS, 1D and 2D NMR spectroscopic methods. Compounds 1, 2, and 4 were reported for the first time from C. pycnocephalus and compounds 5 and 7 were first reported from the genus Carduus. Anti-inflammatory, antispasmodic and hypotensive activities were assessed for all extracts which showed variable activities.

• 出版日期2015-7