An amorphous silicon photodiode microfluidic chip to detect nanomolar quantities of HIV-1 virion infectivity factor

作者：Vistas Claudia R; Soares Sandra S; Rodrigues Rogerio M M; Chu Virginia; Conde Joao P; Ferreira Guilherme N M^*

来源：Analyst, 2014, 139(15): 3709-3713.

DOI：10.1039/c4an00695j

A hydrogenated amorphous silicon (a-Si: H) photosensor was explored for the quantitative detection of a HIV-1 virion infectivity factor (Vif) at a detection limit in the single nanomolar range. The a-Si: H photosensor was coupled with a microfluidic channel that was functionalized with a recombinant single chain variable fragment antibody. The biosensor selectively recognizes HIV-1 Vif from human cell extracts.

• 出版日期2014