科研之友
微信
新浪微博
Facebook
分享链接
摘要
Purpose. To investigate the uptake and delivery of the anti-allergy drug ketotifen fumarate (KF) by commercially available contact lenses. %26lt;br%26gt;Methods. A total of 14 different commercially available contact lenses were investigated, including five frequent-replacement silicone hydrogels, three conventional hydrogels, and six daily disposable lenses. Lenses were soaked in a 0.025% KF loading solution for 24 h, and the concentration of KF in solution over time was determined by ultraviolet absorbance at 297 nm. After the 24-h loading period, lenses were placed in fresh vials containing borate buffered saline, and the release of drug into solution at 34 degrees C was monitored for 24 h. %26lt;br%26gt;Results. All the lenses studied demonstrated significant uptake and release of KF into the borate buffered saline (p %26lt; 0.05 compared with initial time point). Lenses with charged surfaces [balafilcon A, etafilcon A, and etafilcon A (daily disposable)] demonstrated the greatest uptake and release of KF. Etafilcon A released 284.5 +/- 29.8 mu g/lens, whereas balafilcon A released 227.6 +/- 14.7 mu g/lens, which was substantially more (p %26lt; 0.05) than the lowest releasing lenses [nelfilcon A (40.4 +/- 4.1 mu g/lens) and comfilcon A (110.4 +/- 8.9 mu g/lens)]. The majority of lenses were able to match or exceed the total amount of KF commonly administered to the eye using twice-daily dosing of commercially available (0.025%) eye drop formulations. Most of the lenses surveyed reached a plateau concentration of KF relatively quickly, and no lens was able to release KF for longer than 4 h. %26lt;br%26gt;Conclusions. Commercially available lenses demonstrated the ability to release a clinically relevant amount of KF compared with conventional eye drops. The use of commercially available contact lenses as a KF delivery system in a daily wear scenario may be feasible. (Optom Vis Sci 2012;89:1140-1149)
- 出版日期2012-8
