科研之友
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摘要
Tortuosity is an important geometric vessel parameter and among the first microvascular alterations observed in various retinopathies. In the current study, a quantitative vessel tortuosity index (VTI) based on a combination of local and global centerline features is presented. Performance of VTI and previously established tortuosity indices were compared against human observers' evaluation of tortuosity. An image-processing pipeline was developed for application of VTI in retinal vessels imaged by optical coherence tomography angiography (OCTA) in perifoveal (6 mm x 6 mm) and parafoveal (3 mm x 3 mm) regions centered on the fovea. Forty-one subjects (12 healthy control (NC) and 29 sickle cell retinopathy (SCR)) and 10 subjects (5 NC and 5 SCR) were imaged in the perifoveal and parafoveal regions, respectively. The relationship between VTI and age was examined in the perifoveal regions in NC subjects. VTI was measured from the OCTA images and compared between NC and SCR subjects using generalized least square regression with and without adjusting for age and race. VTI was found to correlate better than the 4 previous indices with performance of human observers. In the perifoveal region, a significant correlation was observed between VTI and age (r = -0.4, P<0.001, N = 12). VTI was higher in SCR than NC subjects in perifoveal and parafoveal regions (P <= 0.001). The results demonstrate that the proposed method shows promise for detection of increased tortuosity in vessels due to retinal disorders.
- 出版日期2017-8-1
