Association of human leukocyte antigen class II alleles with pemphigus vulgaris in a Turkish population

作者：Tunca Mustafa^*; Musabak Ugur; Sagkan Rahsan Ilikci; Koc Erol; Akar Ahmet

来源：Journal of Dermatology, 2010, 37(3): 246-250.

DOI：10.1111/j.1346-8138.2009.00743.x

• class II allele
• haplotype
• human leukocyte antigen
• pemphigus vulgaris
• Turkish patients

Pemphigus vulgaris (PV) is a severe autoimmune blistering skin disorder that is strongly associated with major histocompatibility complex class II alleles. Human leukocyte antigen (HLA) subtypes vary with racial/ethnic backgrounds. The purpose of this study was to determine the association of HLA class II alleles and haplotypes with PV in Turkish patients. Twenty-five patients with PV and 113 healthy transplant donors were genotyped for HLA class II alleles. HLA DNA typing was performed by the polymerase chain reaction/sequence specific primer method. The frequency of HLA DRB1*04 allele was 68.00% in patients compared to 30.97% in controls (P = 0.0012) and the frequency of HLA DRB1*14 allele was 32.00% in the patient group compared to 8.85% in the control group (P = 0.0054). Also, the frequency of HLA DRB1*04/DQB1*03 and HLA DRB1*14/DQB1*05 haplotypes in PV patients was significantly higher than controls (32.0% vs 6.2%, chi 2 = 28.142, P < 0.001; and 16% vs 2.7%, chi 2 = 15.143, P = 0.001, respectively). A preventive allele or haplotype for the manifestation of PV has not been identified in this study. Our findings suggest that HLA DRB1*04 and DRB1*14 alleles, and HLA DRB1*04/DQB1*03 and HLA DRB1*14/DQB1*05 haplotypes are genetic markers for general susceptibility to PV in the Turkish population.

• 出版日期2010-3
• 单位中国人民解放军军事医学科学院