Antidepressant, Myorelaxant and Anti-Anxiety-Like Effects of Nauclea latifolia Smith (Rubiaceae) Roots Extract in Murine Models

作者：Taiwe G S^*; Bum E Ngo; Dimo T; Talla E; Weiss N; Dawe A; Moto F C O; Sidiki N; Dzeufiet P D; De Waard M

来源：International Journal of Pharmacology, 2010, 6(4): 364-371.

• Nauclea latifolia
• neuropharmacology
• antidepressant
• myorelaxant
• anti-anxiety

The neuropharmacological effects of the decoction of Nauclea latifolia Smith (Rubiaceae) roots were studied in mice Different experimental models (forced swimming test, horizontal wire test and hole-board test) were used for detecting antidepressant, myorelaxant and anxiolytic properties The results revealed that Nauclea latifolia induced a reduction of immobility, in a similar way to that of fluoxetine, along with a significant increase in the percentage of spent time in swimming behavior Nauclea latifolia displayed a myorelaxant activity in the horizontal wire test In the hole-board test, Nauclea laufolta significantly increased the number and duration of head-dips In addition, anxiolytic-like properties of Nauclea laufolta were blocked by anxiogenic agents as examined in the hole-board test This was the case for N-methyl-beta-carboline-3-carboxamide (FG7142), a partial Inverse agonist at the benzodiazepine site of the GABA(A) receptor complex, flumazenil (RO151788), a central benzodiazepine receptor antagonist and bicuculline, a light-sensitive competitive antagonist of GABA(A) receptors These results suggest that Nauclea latifolia roots decoction possess antidepressant, myorelaxant and anti-anxiety-like properties in the models employed The extracts might potentially act by GABAergic activation and/or by modulating the serotoninergic levels in the central nervous system However, further studies were still required

• 出版日期2010-8