ADP Receptor-Blocker Thienopyridines: Chemical Structures, Mode of Action and Clinical Use. A Review

作者：Hashemzadeh Mehrnoosh^*; Gold**erry Sarah; Furukawa Matthew; Khoynezhad Ali; Movahed Mohammad Reza

来源：Journal of Invasive Cardiology, 2009, 21(8): 406-412.

• clopidogrel
• ticlopidine
• prasugrel
• acute coronary syndrome
• antiplatelet
• antagonist
• antithrombotic stenting

One of the major classes of adenosine diphosphate (ADP) receptor antagonists are thienopyridines Thienopyridines corn pose a subcategory of antiplatelet medications known as ADP receptor inhibitors used commonly for the treatment of atherosclerotic cardiovascular disease Thienopyridines including ticlopidine clopidogrel and prasugrel, are prodrugs administered orally that are further metabolized by hepatocytes to create active metabolites that irreversibly bind ADP receptors located on the platelet membrane Thus these selected drugs have an inhibitory effect for the duration of the platelet s lifespan of 7-10 days The goal of this manuscript is to review the currently avail able ADP receptor blockers with emphasis on chemical structure mode of action and clinical use

• 出版日期2009-8