mTOR inhibitor-associated dermatologic and mucosal problems

作者：Campistol Josep M; de Fijter Johan W; Flechner Stuart M^*; Langone Anthony; Morelon Emmanuel; Stockfleth Eggert

来源：Clinical Transplantation, 2010, 24(2): 149-156.

DOI：10.1111/j.1399-0012.2010.01232.x

• dermatologic complications
• immunosuppression
• renal transplantation
• sirolimus

Mammalian target of rapamycin inhibitor use is associated with numerous adverse events, including dermatologic and mucosal problems. Awareness of these complications, which clinically manifest across a severity spectrum from minor through severe and may occur at varied time points after initiation of sirolimus therapy, can be useful to clinicians in both managing these events and determining the appropriate intervention(s) for patients. This manuscript examines the dermatologic and mucosal problems associated with mammalian target of rapamycin inhibitor use, reviews the literature, and provides personal experiences regarding the management and treatment of these adverse events.

• 出版日期2010-4