Depression in patients with head and neck cancer and a functional genetic polymorphism of the serotonin transporter gene

作者：Gilbert Jill^*; Haman Kirsten L; Dietrich Mary S; Blakely Randy D; Shelton Richard C; Murphy Barbara A

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2012, 34(3): 359-364.

DOI：10.1002/hed.21744

• serotonin
• head and neck cancer
• depression
• 5-HTTLPR
• polymorphism

Background Polymorphism of the serotonin transporter gene, 5-HTTLPR (short allele) has been associated with depression. The purpose of this study was to show the evaluated depression in patients with head and neck cancer and a possible association with the 5-HTTLPR.
Methods. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (SCID for DSM-IV) was administered to 94 patients with head and neck cancer, of which 33 patients were genotyped for 5-HTTLPR. We also evaluated the prevalence of 5-HTTLPR polymorphism in 121 patients with head and neck cancer and 97 controls.
Results. Forty-three percent of the patients met the criteria for a depressive diagnosis, 19% of which was new onset. In depressed patients, 85.7% (n = 12 of 14) had at least 1 short allele versus 68.4% (n = 13 of 19) of the patients without depressive diagnosis (p < .04). No difference was noted in the prevalence of the short allele in head and neck cancer cases versus controls (odds ratio 0.8; p = .490).
Conclusion. Despite the high rate of depressive diagnosis, patients with head and neck cancer did not demonstrate a higher prevalence of this short allele of the 5-HTTLPR compared with a control population.

• 出版日期2012-3