Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

作者：Kim Seongchan; Ryoo Soo Ryoon; Na Hee Kyung; Kim Young Kwan; Choi Byong Seok; Lee Younghoon; Kim Dong Eun; Min Dal Hee^*

来源：Chemical communications, 2013, 49(74): 8241-8243.

DOI：10.1039/c3cc43368d

The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.

• 出版日期2013