Analysis of multiple factors related to hematologic toxicity following (SM)-S-153-EDTMP therapy

作者：Liu Hongbiao; Zhan Hongwei^*; Sun Da; Xu Wei; Ye Xiaojuan; Zhang Hong; Zhao Chunlei; Bao Chengkan; He Gangqiang; Yin Feng

来源：Cancer Biotherapy and Radiopharmaceuticals, 2007, 22(4): 515-520.

DOI：10.1089/cbr.2007.350

• Sm-153-EDTMP therapy
• hematologic toxicity
• factor analysis

Purpose: The aim of this study was to investigate the clinical factors related to hematologic toxicity caused by treatment with samarium-153 ethylenediaminetetramethylene phosphonic acid ((SM)-S-153-EDTMp). Materials and Methods: A total of 206 secondary bone neoplasm patients treated with Sm-153-EDTMP were analyzed retrospectively. Logistic regression (SPSS 10.0for Windows; Chicago, IL) and correlation analysis were used to evaluate the factors concerned. Results: Age, number of bone metastatic lesions, chemotherapy before treatment with (SM)-S-153-EDTMP, concurrence of radiotherapy, and times of repeated treatments with (SM)-S-153-EDTMP were determined by singlefactor analysis to be related to hematologic toxicity. Chemotherapy before treatment with (SM)-S-153-EDTMP, concurrence of radiotherapy, drug use to maintain normal white blood cell counts, and times of repeated treatments with (SM)-S-153-EDTMP were determined by multiplefactor analysis to be related to hematologic toxicity. Conclusions: Chemotherapy before treatment with (SM)-S-153-EDTMP, concurrence of radiotherapy, drug use to maintain normal white blood cell counts, and times of repeate treatments with Sm-153-EDTMP are the main clinicalfactors related to hematologic toxicity caused by (SM)-S-153-EDTMP therapy. In patients with such factors, more attention might be paid to the change of blood cell counts after (SM)-S-153-EDTMp therapy.

• 出版日期2007-8
• 单位浙江大学