A Practical Synthetic Route to Enantiopure 6-Substituted cis-Decahydroquinolines

作者:Amat Mercedes*; Navio Laura; Llor Nuria; Molins Elies; Bosch Joan
来源:Organic Letters, 2012, 14(1): 210-213.
DOI:10.1021/ol2030058

摘要

Starting from 4-substituted cyclohexanones, a practical synthetic route to enantlopure 6-substituted cis-decahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of an unsaturated (5-keto ester derivative with (R)-phenyiglyclnol and the stereoselective hydrogenation of the resulting tricyclic oxazoloquinolone lactams.

  • 出版日期2012-1-6