Antithrombogenic and antiplatelet activity of optho-isobornyl phenol derivative

作者：Plotnikov M B^*; Smolyakova V I; Ivanov I S; Kuchin A V; Chukicheva I J; Krasnov E A

来源：Bulletin of Experimental Biology and Medicine, 2008, 145(3): 328-330.

DOI：10.1007/s10517-008-0082-x

• thrombosis
• ischemia
• ortho-isobornyl phenol
• sterically hindered phenols

We studied antithrombogenic and antiplatelet properties of 4-methyl-2,6-diisobornyl phenol, a new promising compound belonging to ortho-isobornyl phenol derivatives, under conditions of intravascular thrombosis and acute cerebral ischemia. It was found that 4-methyl-2,6-diisobornyl phenol prevents intravascular thrombus formation by reducing platelet aggregation and improving antiplatelet activity of the vascular wall.

• 出版日期2008-3