A pilot randomized trial of two cognitive rehabilitation interventions for mild cognitive impairment: caregiver outcomes

作者：Cuc Andrea V; Locke Dona E C^*; Duncan Noah; Fields Julie A; Snyder Charlene Hoffman; Hanna Sherrie; Lunde Angela; Smith Glenn E; Chandler Melanie

来源：International Journal of Geriatric Psychiatry, 2017, 32(12): E180-E187.

DOI：10.1002/gps.4689

• mild cognitive impairment
• caregivers
• behavioral intervention
• cognitive rehabilitation

ObjectiveThis study aims to provide effect size estimates of the impact of two cognitive rehabilitation interventions provided to patients with mild cognitive impairment: computerized brain fitness exercise and memory support system on support partners' outcomes of depression, anxiety, quality of life, and partner burden.
MethodsA randomized controlled pilot trial was performed.
ResultsAt 6months, the partners from both treatment groups showed stable to improved depression scores, while partners in an untreated control group showed worsening depression over 6months. There were no statistically significant differences on anxiety, quality of life, or burden outcomes in this small pilot trial; however, effect sizes were moderate, suggesting that the sample sizes in this pilot study were not adequate to detect statistical significance.
ConclusionEither form of cognitive rehabilitation may help partners' mood, compared with providing no treatment. However, effect size estimates related to other partner outcomes (i.e., burden, quality of life, and anxiety) suggest that follow-up efficacy trials will need sample sizes of at least 30-100 people per group to accurately determine significance.

• 出版日期2017-12