Anticancer and alpha-chymotrypsin inhibiting diterpenes and triterpenes from Salvia leriifolia

作者：Choudhary M Iqbal^*; Hussain Amjad; Adhikari Achyut; Marasini Bishnu P; Sattar Samina A; Atia tul Wahab; Hussain Nusrat; Ayatollahi Syed A Majid; Atta ur Rahman

来源：Phytochemistry Letters, 2013, 6(1): 139-143.

DOI：10.1016/j.phytol.2012.11.010

• Salvia leriifolia
• Lamiaceae
• Abietane-type diterpenoids
• Prostate cancer cell lines
• Cervical cancer cell lines
• alpha-Chymotrypsin inhibition

Salvialeriol (1), a new abietane-type diterpene, was isolated from Salvia leriifolia Benth. (Salvia leriaefolia), along with two known abietane-type diterpenoids, 6-hydroxysalvinolone (2) and deacetylnemorone (3), and two known triterpenes, 2-acetoxylupeol (4), and lupine-2,3-diol (5). Compounds 2-5 are reported here for the first time from this species. Compound 4 was previously reported as a synthetic derivative of 5 and this is the first report of its isolation from a natural source. Compounds 2, 3 and 5 exhibited a potent antiproliferative activity against the prostate cancer cell lines (PC3) with IC50 of 3.9 +/- 0.1, 6.2 +/- 0.1 and 2.8 +/- 0.1 mu M, respectively, and cervical cancer cell lines (HeLa) with IC50 of 8.0 +/- 0.3, 2.6 +/- 0.1 and 2.7 +/- 0.1 mu M, respectively. Whereas compounds 1 and 4 showed moderate antiproliferative activities against the cell lines. Compounds 1-5 were also evaluated for the inhibition of alpha-chymotrypsin, a protease enzyme, and 2 exhibited a competitive inhibition of the enzyme (IC50 = 188.8 mu M).

• 出版日期2013-2