ASSESSMENT OF THE ANTI-DIARRHEA FUNCTION OF COMPOUND CHINESE HERBALMEDICINE CANGPO ORAL LIQUID

作者：Xia, Xinchao^*; Wang, Hui; Niu, Xu; Wang, Haijun; Liu, Zhiqi; Liu, Yongming; Qi, Zhiming; Wang, Shengyi; Liu, Shixiang; Liu, Shanshan

来源：African Journal of Traditional, Complementary and Alternative Medicines, 2014, 11(1): 140-147.

DOI：10.4314/ajtcam.v11i1.22

• Cangpo Oral Liquid
• therapeutic effect
• peristalsis
• herbal

Background: Diarrhea is a big problem in piglets. Cangpo Oral Liquid (COL) is a compound of Chinese herbal medicine. The preparation was fed to piglets had diarrheal disease in order to determine its anti-diarrhea activity and potential applications in vivo.
Materials and Methods: The contents of Berberine hydrochloride, Magnolol and Honokiol in COL were performed on HPLC analysis. Organ bath was used to investigate the effect of COL on peristaltic reflexes and peristaltic waves in vitro. And anti-diarrhea activity of COL was evaluated in clinical.
Results: Thin layer chromatography (TLC) and HPLC analyses showed that the contents of Berberine hydrochloride, Magnolol and Honokiol in COL were 970 mu g/mL, 130 mu g/mL and 300 mu g/mL, respectively. Administration of the COL to the organ bath caused a concentration-dependent inhibition of intestinal peristalsis. When the COL concentration in the bath was cumulatively increased, the amplitude and frequency of the peristaltic waves was lowered. The result of clinical efficacy of COL was very effective to diarrheic piglets. COL can possibly inhibit the curve of peristaltic waves in vitro; and clinical trial showed a statistically significant therapeutic effect in vivo.
Conclusion: In conclusion, COL can be used as an effective therapeutic agent. However, the ingredients, pharmacokinetics and specific signaling pathways of COL need to be further studied.

• 出版日期2014
• 单位中国农业科学院