Engaging neuroscience to advance translational research in brain barrier biology

作者：Neuwelt Edward A^*; Bauer Bjoern; Fahlke Christoph; Fricker Gert; Iadecola Constantino; Janigro Damir; Leybaert Luc; Molnar Zoltan; O'Donnell Martha E; Povlishock John T; Saunders Norman R; Sharp Frank; Stanimirovic Danica; Watts Ryan J; Drewes Lester R

来源：Nature Reviews Neuroscience, 2011, 12(3): 169-182.

DOI：10.1038/nrn2995

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and-when barrier integrity is impaired-in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

• 出版日期2011-3