Discontinuation of statin therapy due to muscular side effects: A survey in real life

作者：Rosenbaum D^*; Dallongeville J; Sabouret P; Bruckert E

来源：Nutrition Metabolism and Cardiovascular Diseases, 2013, 23(9): 871-875.

DOI：10.1016/j.numecd.2012.04.012

• Statins
• Muscular symptoms
• Side effects
• Real life survey
• Dyslipidemia

Backgrounds and aims: To assess the burden of statin related muscular symptom in real life.
Methods and results: We conducted a wide survey on 10,409 French subjects. Among these, 2850 (27%) had hypercholesterolemia and 1074 were treated with statins. Muscular symptoms were reported by 104 (10%) statin treated patients and led to discontinuation in 30% of the symptomatic patients. The main prescribed statins were low doses rosuvastatin, atorvastatin and simvastatin. Pains were the most commonly described symptoms (87%) but many patients also reported stiffness (62%), cramps (67%), weakness or a loss of strength during exertion (55%). Pain was localized in 70% but mostly described as affecting several muscular groups. Approximately 38% of patients reported that their symptoms prevented even moderate exertion during everyday activities, while 42% of patients suffered major disruption to their everyday life.
Conclusion: Muscular symptoms associated with average dosage statin therapy are more frequent than in clinical trials and have a greater impact on patients' life than usually thought.

• 出版日期2013-9