A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome

作者：Fuller Brian M^*; Ferguson Ian T; Mohr Nicholas M; Drewry Anne M; Palmer Christopher; Wessman Brian T; Ablordeppey Enyo; Keeperman Jacob; Stephens Robert J; Briscoe Cristopher C; Kolomiets Angelina A; Hotchkiss Richard S; Kollef Marin H

来源：Critical Care Medicine, 2017, 45(4): 645-652.

DOI：10.1097/CCM.0000000000002268

• acute respiratory distress syndrome
• emergency department
• lung-protective ventilation

Objectives: To evaluate the impact of an emergency department mechanical ventilation protocol on clinical outcomes and adherence to lung-protective ventilation in patients with acute respiratory distress syndrome.
Design: Quasi-experimental, before-after trial.
Setting: Emergency department and ICUs of an academic center. Patients: Mechanically ventilated emergency department patients experiencing acute respiratory distress syndrome while in the emergency department or after admission to the ICU.
Interventions: An emergency department ventilator protocol which targeted variables in need of quality improvement, as identified by prior work: 1) lung-protective tidal volume, 2) appropriate setting of positive end-expiratory pressure, 3) oxygen weaning, and 4) head-of-bed elevation.
Measurements and Main Results: A total of 229 patients (186 pre-intervention group, 43 intervention group) were studied. In the emergency department, the intervention was associated with significant changes (p < 0.01 for all) in tidal volume, positive end-expiratory pressure, respiratory rate, oxygen administration, and head-of-bed elevation. There was a reduction in emergency department tidal volume from 8.1 mL/kg predicted body weight (7.0-9.1) to 6.4 mL/kg predicted body weight (6.1-6.7) and an increase in lung-protective ventilation from 11.1% to 61.5%, p value of less than 0.01. The intervention was associated with a reduction in mortality from 54.8% to 39.5% (odds ratio, 0.38; 95% CI, 0.17-0.83; p= 0.02) and a 3.9 day increase in ventilator-free days, p value equals to 0.01.
Conclusions: This before-after study of mechanically ventilated patients with acute respiratory distress syndrome demonstrates that implementing a mechanical ventilator protocol in the emergency department is feasible and associated with improved clinical outcomes. (Crit Care Med 2017; 45:645-652)

• 出版日期2017-4