A randomized controlled clinical study of the effect of daily intake of Ascophyllum nodosum alga on calculus, plaque, and gingivitis

作者：van Dijken Jan W V^*; Koistinen S; Ramberg Per

来源：Clinical Oral Investigations, 2015, 19(6): 1507-1518.

DOI：10.1007/s00784-014-1383-2

• Alga
• Ascophyllum nodosum
• Calculus
• Clinical
• Gingivitis
• Plaque
• Seaweed

Objective The aim of this study is to evaluate, in a randomized controlled cross-over study, the effect of daily intake of the alga Ascophyllum nodosum on supragingival calculus, plaque formation, and gingival health over a 6-month period.
Material and methods Sixty-one adults with moderate to heavy calculus formation since their last yearly recall visit participated. In a randomized order over two 6-month periods, they swallowed two capsules daily, comprising a total of 500 mg dried marine alga powder (Ascophyllum nodosum, ProDen PlaqueOff (R)) or two negative control tablets. During the study, the participants maintained their regular oral habits. Their teeth were professionally cleaned at the start of each period and after the 6-month registrations. Awash out period of 1 month separated the two 6-month periods. Supragingival calculus (VolpeManhold), gingivitis (Loe and Silness), gingival bleeding (Ainamo and Bay), and plaque (Quigley-Hein) were registered at screening and at the end of the two periods. Differences in oral health between the test and control periods were analyzed using a paired t test and Wilcoxon signed rank test.
Results Fifty-five participants completed the study. After the alga intake, the mean calculus reduction was 52% compared to the control (p<0.0001). Fifty-two participants showed less calculus formation in the alga group than in the control group. Plaque (p=0.008) and gingival bleeding (p=0.02) were also significantly less in the alga group. However, no significant difference was found between the groups for gingivitis (p=0.13).
Conclusions The alga intake significantly reduced the formation of supragingival calculus and plaque and occurrence of gingival bleeding. The alga has a systemic effect on oral health.
Clinical relevance Daily intake of the alga Ascophyllum nodosum as an adjunct to customary oral hygiene showed a major reduction of supragingival calculus formation and reduced plaque formation. In addition, the calculus in the alga group was characterized by a more porous and less solid structure and was easier to remove than the calculus in the control group.

• 出版日期2015-7