Unpinning of rotating spiral waves in cardiac tissues by circularly polarized electric fields

作者：Feng, Xia; Gao, Xiang; Pan, De-Bei; Li, Bing-Wei; Zhang, Hong^*

来源：Scientific Reports, 2014, 4(1): 4831.

DOI：10.1038/srep04831

• EXCITABLE MEDIA
• WINFREE TURBULENCE
• SCROLL WAVES
• DEFIBRILLATION
• HETEROGENEITY
• FIBRILLATION
• STIMULATION
• SHOCKS
• MODEL
• ORGANIZATION

Spiral waves anchored to obstacles in cardiac tissues may cause lethal arrhythmia. To unpin these anchored spirals, comparing to high-voltage side-effect traditional therapies, wave emission from heterogeneities (WEH) induced by the uniform electric field (UEF) has provided a low-voltage alternative. Here we provide a new approach using WEH induced by the circularly polarized electric field (CPEF), which has higher success rate and larger application scope than UEF, even with a lower voltage. And we also study the distribution of the membrane potential near an obstacle induced by CPEF to analyze its mechanism of unpinning. We hope this promising approach may provide a better alternative to terminate arrhythmia.

• 出版日期2014-4-29
• 单位浙江大学; 杭州师范大学