Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest: A multicentre experience

作者：Dennis Mark; McCanny Peter; D' Souza Mario; Forrest Paul; Burns Brian; Lowe David A; Gattas David; Scott Sean; Bannon Paul; Granger Emily; Pye Roger; Totaro Richard

来源：International Journal of Cardiology, 2017, 231: 131-136.

DOI：10.1016/j.ijcard.2016.12.003

• Cardiopulmonary resuscitation
• CPR
• Extracorporeal membrane oxygenation
• ECMO
• ECPR
• Cardiac arrest
• ELS
• ECLS

Aim: To describe the ECPR experience of two Australian ECMO centres, with regards to survival and neurological outcome, their predictors and complications. Methods: Retrospective observational study of prospectively collected data on all patients who underwent extracorporeal cardiopulmonary resuscitation (ECPR) at two academic ECMO referral centres in Sydney, Australia.
Measurements and main results: Thirty-seven patients underwent ECPR, 25 (68%) were for in-hospital cardiac arrests. Median age was 54 (IQR 47-58), 27 (73%) were male. Initial rhythm was ventricular fibrillation or pulseless ventricular tachycardia in 20 patients (54%), pulseless electrical activity (n= 14, 38%), and asystole (n= 3, 8%). 27 (73%) arrests were witnessed and 30 (81%) patients received bystander CPR. Median time from arrest to initiation of ECMO flow was 45min (IQR 30-70), and the median time on ECMO was 3 days (IQR 1-6). Angiography was performed in 54% of patients, and 27% required subsequent coronary intervention (stenting or balloon angioplasty 24%). A total of 13 patients (35%) survived to hospital discharge (IHCA 33% vs. OHCA 37%). All survivors were discharged with favourable neurological outcome (Cerebral Performance Category 1 or 2). Pre-ECMO lactate level was predictive of mortality OR 1.35 (1.06-1.73, p = 0.016).
Conclusions: In selected patients with refractory cardiac arrest, ECPR may provide temporary support as a bridge to intervention or recovery. We report favourable survival and neurological outcomes in one third of patients and pre-ECMO lactate levels predictive of mortality. Further studies are required to determine optimum selection criteria for ECPR.

• 出版日期2017-3-15