New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E

作者：Sebode Marcial^*; Pischke Sven; Luetgehetmann Marc; Polywka Susanne; Quaas Alexander; Lohse Ansgar W; Wege Henning

来源：BMC Gastroenterology, 2014, 14(1): 191.

DOI：10.1186/s12876-014-0191-0

• Hepatitis E
• Autochthonous
• Acute liver injury
• Steroid treatment

Background: Autochthonous hepatitis E has been observed with growing incidence in industrialized countries. Hepatitis E virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. However, in individual cases, hepatitis E may lead to life-threatening acute liver failure. In this report, we describe a case of acute liver injury caused by an autochthonous hepatitis E that resolved under steroid treatment. To our knowledge, this is the first case report describing supportive steroid monotherapy for acute liver injury due to hepatitis E.
Case presentation: A 63-year-old Caucasian male presented with acute liver injury of unknown origin. After excluding the most prevalent causes of acute liver injury, liver histology revealed signs of immune-mediated toxic or drug-induced liver injury. Therefore, immunosuppressive treatment with prednisolone was started. After initialization of steroid treatment, polymerase chain reaction analyses of peripheral blood and liver tissue revealed an acute hepatitis E virus infection (genotype 3). Under sustained steroid treatment, acute liver injury improved and hepatitis E infection resolved.
Conclusion: Steroid treatment might be an option to prevent progress of life-threatening liver failure and liver transplantation in patients with hepatitis E-induced acute liver injury and high-grade inflammation.

• 出版日期2014-11-15