Direct Metal-Free Preparation of Functionalizable Polylactic Acid-Ethisterone Conjugates in a One-Pot Approach

作者：Luo, Shi-He; Wu, Yan-Cheng; Cao, Bang; Lin, Dian-Yun; Gao, Jian; Chen, Shui-Xia^*; Wang, Zhao-Yang^*

来源：Macromolecular Chemistry and Physics, 2019, 220(5): 1800475.

DOI：10.1002/macp.201800475

• biomaterials
• copolymerization
• drug delivery systems
• functionalization of polymers
• polycondensation

A series of polylactic acid (PLA) conjugates (PLA-ES) are synthesized via direct melt polycondensation (DMP) of lactic acid (LA) with ethisterone (ES) in the presence of 0.3 wt% toluenesulfonic acid at 160 degrees C for 6 h. The drug content of PLA conjugates can be simply adjustable. Further functionalization via Click chemistry is also achieved to extend the biomedicine application of biopolymer based drug delivery.

• 出版日期2019-3
• 单位华南师范大学; 华南理工大学; 中山大学